Knowledge map
Save
Objective: To analyse the risk factors for urinary tract infection (UTI) in children and construct and validate a risk prediction model.
Methods: The study selected 258 children with suspected UTI in the paediatric department of our hospital from August 2019 to August 2021. Identified as the subjects in this research, paediatric patients’ clinical data were used for retrospective analysis. Based on the counting results of urinary leucocytes and bacteria, children were divided into the UTI group (n = 67) and non-UTI group (n = 191). Univariate analysis and multivariate logistic regression analysis were used to screen the independent risk factors for UTI in children, and a prediction model was constructed according to the results. The Hosmer–Lemeshow goodness-of-fit (GOF) test and receiver operator characteristic (ROC) curve analysis were used to validate the calibration and application value of prediction model.
Results: Logistic regression analysis identified length of hospitalisation ≥10 days (OR = 3.611, 95% CI: 1.781–7.325), indwelling ureter (odds ratio (OR) = 3.203, 95% CI: 1.615–6.349), history of infection (OR = 4.827, 95% CI: 2.424–9.612), congenital malformation/dysplasia (OR = 4.212, 95% CI: 2.079–8.531), constipation (OR = 4.021, 95% CI: 1.315–12.299) and anaemia (OR = 2.275, 95% CI: 1.236–4.186) as risk factors for UTI in children (p < 0.05). The formulation method was adopted to construct the following prediction model of UTI in children: Z = 2.066 × (length of hospitalisation ≥10 days) + 1.164 × (indwelling ureter) + 1.574 × (history of infection) + 1.438 × (congenital malformation/dysplasia) + 1.392 × (constipation) + 0.882 × (anaemia). The test results revealed the good GOF and high calibration (χ2 = 9.077, p = 0.336) of prediction model. Furthermore, the area under the ROC curve was 0.825 (95% CI: 0.766–0.884, p < 0.001), indicating the good discrimination and prediction efficiency of model.
Conclusions: Based on clinical results, further attention should be given to high-risk children with UTI, and intervention measures should be taken immediately. The application and popularisation of prediction model will allow us to provide strategic guidance for preventing and treating UTIs in clinics.
Knowledge map
Save
Objective: The correlation of the degree of hydronephrosis and computed tomography (CT) value of calculi with the efficacy of ureteroscopic lithotripsy (URSL) in patients with upper urinary tract infectious calculi was explored.
Methods: The clinical data of 152 patients with upper urinary tract infectious calculi and on URSL in Shanghai Baoshan District Wusong Central Hospital from November 2019 to November 2021 were collected for retrospective analysis. All patients received CT examination before surgery. According to the therapeutic effect of URSL, all patients were divided into the non-calculi group (NCG, n = 101) and residual calculi group (RCG, n = 51), which were compared in terms of the degree of hydronephrosis and CT value of calculi. Then, the correlation of the degree of hydronephrosis and CT value of calculi with the efficacy of URSL in patients was analysed.
Results: No significant difference in clinical data was found between the groups (p > 0.05). Patients in the NCG group had lower degree of hydronephrosis than those in the RCG group (p < 0.05), and the NCG had lower CT value of calculi (p < 0.001). Spearman rank correlation analysis showed that the degree of hydronephrosis in patients with upper urinary tract infectious calculi was negatively correlated with the efficacy of URSL (r = −0.676, p < 0.001), and the CT value of calculi in such patients was negatively correlated with the efficacy of URSL (r = −0.795, p < 0.001).
Conclusions: The degree of hydronephrosis and CT value of calculi were negatively correlated with the efficacy of URSL. Both can be used to predict clinical efficacy and have clinical guiding value for the formulation of treatment plans in patients with urinary tract infectious calculi.
Knowledge map
Save
Objective: The application value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) texture analysis combined with apparent diffusion coefficient (ADC) in predicting pelvic lymph node metastasis of prostate cancer was explored.
Methods: The clinical and imaging data of 151 patients with prostate cancer admitted to The Affiliated Tumor Hospital of Guizhou Medical University from November 2019 to November 2021 were retrospectively analysed. According to the final pathological diagnosis results, they were divided into two groups: Metastasis group (n = 63, pelvic lymph node metastasis) and non-metastasis group (n = 88, no pelvic lymph node metastasis). The DCE-MRI texture parameters and ADCs of the two groups were compared using Omni-Kinetics software and MADC software packages. The receiver operating characteristic (ROC) curve was used in evaluating the predictive value of each method and their combination, and Spearman rank correlation analysis was used in evaluating their correlation.
Results: The volume transfer (Ktrans) and interstitium-to-plasmarate rate constant (Kep) in the metastatic group were significantly higher than those in the non-metastatic group (p < 0.001). However, no significant difference in extravascular extracellular space volume fraction (Ve) was found between the groups (p > 0.05). The ADC of the metastatic group was lower (p < 0.001). The Ktrans and Kep values were positively correlated with pelvic lymph node metastasis of prostate cancer (r = 0.580, 0.684; p < 0.001), and the ADC was negatively correlated with pelvic lymph node metastasis of prostate cancer (r = −0.478; p < 0.001). The ROC curve showed that the area under the curve (AUC) of DCE-MRI texture analysis parameters Ktrans and Kep combined with ADC was large, and the prediction efficiency increased. The AUC, sensitivity and specificity were 0.974, 95.20% and 93.20% (p < 0.001), respectively.
Conclusions: DCE-MRI texture analysis combined with ADC value can accurately predict pelvic lymphatic metastasis of prostate cancer, which is helpful for the selection and formulation of clinical treatment plans and has certain guiding value for the implementation of pelvic lymph node clearing in patients.
Knowledge map
Save
Objective: To evaluate trends in the prevalence and clinical characteristics of urogenital diseases in hospitalized patients of secondary and tertiary hospitals in Ningbo, an east coast city in China, from 2017 to 2019.
Methods: We collected the data on hospitalized patients in Ningbo secondary and tertiary hospitals from January 1, 2017 to December 31, 2019. The data included age, sex, and diagnosis identified using the International Classification of Diseases (ICD) codes, which were obtained from Ningbo National Health Information Platform. We quantified the epidemiology (age/sex-specific) trend of urogenital system disorders.
Results: From January 2017 to December 2019, there were 256750 hospitalized patients with urogenital system disorders. These hospitalized patients comprised more women than men (1.45:1.00). The number of hospitalized patients with these diseases significantly increased over the 3 years (77505, 89167, and 90078, respectively; Z = 20.03, p < 0.001). The highest prevalence of these diseases was in the 40- to 64-year-old age group (47.37%), followed by the 18- to 39-year-old age group (23.94%). Over the 3 years, the five most common diseases in hospitalized male patients were male reproductive organ disorders, urolithiasis, tubulointerstitial disease, renal failure, and glomerular disease; Whereas the five most common diseases in hospitalized female patients were non-inflammatory disorders of the female genital tract, benign or dynamic undetermined tumors of the female reproductive organs, disorders of breast (according to ICD-10, disorders of breast (N60–N64) were involved in urogenital system diseases (N00–N99)), inflammatory diseases of female pelvic organs, and renal tubulointerstitial disease. In addition, the number of inpatients with renal tubulointerstitial disease significantly increased from 5952 to 9616 over the 3 years (rank increased from 6 to 3).
Conclusions: Patients with urogenital system disorders significantly increased over the 3 years, occurring more often in women and most commonly in young and middle-aged people, which warrants more attention in clinical practice.
Knowledge map
Save
Objective: This study aimed to explore the application of quantitative parameters of computed tomography (CT) texture combined with the detection of serum manganese superoxide dismutase (MnSOD) in the diagnosis of adrenocortical adenoma (ACA).
Methods: The study selected 147 patients with suspected ACA received in Yantaishan Hospital from November 2019 to November 2021 as the research objects. These patients were divided into the study group (SG, n = 71, ACA) and the reference group (RG, n = 76, non-ACA) according to the postoperative pathological results to implement CT examination and subsequent serological examination. The quantitative parameters of CT texture and serum MnSOD levels were compared between the two groups, and the receiver operating characteristic curve was used to evaluate the value of single and combined diagnosis of quantitative parameters of CT texture and detection of serum MnSOD.
Results: Compared with the RG, the SG had notably lower CT values in the plain scan, venous and delayed phase (p < 0.001) and had overtly higher entropy (p < 0.001). However, no remarkable difference was observed in terms of kurtosis and skewness between the two groups (p > 0.05). The serum MnSOD levels of the SG and RG were 27.26 (24.56, 30.97) U/mL and 43.45 (41.02, 45.08) U/mL, respectively, and the MnSOD level of the SG was significantly lower than that of the RG (p < 0.001). The combined diagnosis of CT entropy parameter and MnSOD detection had higher area under the curve (0.91), sensitivity (88.70%) and specificity (82.90%) than those of each single diagnosis (p < 0.001) and had higher diagnostic efficiency.
Conclusions: The entropy in the quantitative parameters of CT texture and detection of MnSOD can be used for the diagnosis of ACA, and their combined diagnosis effect is good, thus providing a new direction for the clinical identification of the disease.
Knowledge map
Save
Background: In this study, the clinical effect of lamivudine combined with leflunomide and methylprednisolone in the treatment of hepatitis B virus-associated glomerulonephritis (HBV-GN) and their influence on renal function indexes was explored.
Methods: Patients with HBV-GN were selected for retrospective analysis and divided into the group B and group A, with 41 cases in each group. The group B was given leflunomide and methylprednisolone, whereas the group A was supplemented with lamivudine. The level of 24 h proteinuria (PRO), albumin (ALB), beta2-microglobulin (β2-MG), alanine aminotransferase (ALT), interferon-gamma (IFN-γ) and interleukin-4 (IL-4) in two groups was measured. The clinical efficacy, adverse reactions appetite, spirit, sleep and daily life scores of the two groups were recorded.
Results: With the extension of treatment time to end of the treatment, the level of 24 h PRO, ALB and β2-MG in the group A significantly changed compared with that before treatment (p < 0.05). Moreover, the level of ALT, IFN-γ and IL-4 in the two groups significantly decreased compared with that before treatment, and the level of the three indexes in the group A decreased more significantly (p < 0.05). The total effective rate in the group A was higher than that in the group B (p < 0.05). The occurrence of adverse reactions showed no statistically significant difference between the two groups. After treatment, scores of appetite, spirit, sleep and daily living were increased in the two groups, and the increase in the group A was more significant than that in the group B (p < 0.05).
Conclusions: Lamivudine combined with methylprednisolone and leflunomide treatment is conducive to clearing Hepatitis B virus (HBV) and improving renal function.
Knowledge map
Save
Objective: This paper aims to explore the prognostic factors of intensity-modulated radiotherapy (IMRT) in patients with bladder cancer by Cox regression analysis and to provide evidence for prolonging the survival of patients and improving the treatment status.
Methods: A total of 153 cases of patients with bladder cancer who received IMRT were selected as research objects, and their clinical data were retrospectively analyzed and followed up. Kaplan–Meier survival analysis was conducted to calculate the median survival period, univariate and multivariate Cox regression were used to analyze the prognostic factors of IMRT in patients with bladder cancer, and receiver operating characteristic curve was adopted to evaluate the prediction efficiency of influencing factors.
Results: Patients were followed up for 9–40 months, and 55 patients died by the end of the follow-up. The median survival time was 30 months, and the 3-year survival rate was 64.05% (98/153). Univariate analysis showed that T stage, total cystectomy, lymph node, pathological type and hydronephrosis influenced the prognosis of IMRT for patients with bladder cancer (p < 0.05). Multivariate Cox regression analysis showed T3 stage (odds ratio (OR) = 0.149, 0.068–0.327), T4 stage (OR = 27.639, 3.677–207.758), lymph node presence (OR = 0.152, 0.050–0.467), pathological type (OR = 0.086, 0.025–0.296) and hydronephrosis (OR = 7.402, 1.161–47.192) were independent factors affecting the prognosis of IMRT in patients with bladder cancer (p < 0.05), while total cystectomy (OR = 1.037, 0.171–6.301) was not an independent factor affecting the prognosis of IMRT in patients with bladder cancer (p > 0.05).
Conclusions: T stage, lymph nodes, nontransitional cell carcinoma with pathological type and hydronephrosis can influence the prognostic effect of IMRT in patients with bladder cancer.
Knowledge map
Save
Objective: The influencing factors of quality of life (QOL) in patients with type 2 diabetic nephropathy (T2DN) were explored, a practical risk prediction model was constructed and independent verification was conducted.
Methods: The clinical data of 273 patients with T2DN in Tai’an Maternal and Child Health Care Center from February 2021 to February 2023 were used for retrospective analysis, and the patients were divided into modelling group (n = 173) and validation group (n = 100). According to 36-item short form health survey (SF-36) scores, the research subjects in the modelling group were divided further into poor group (n = 78) and good group (n = 95). Multivariate logistic regression was used in analysing the influencing factors of QOL and establishing a clinical prediction model based on the results. Then, a receiver operating characteristic (ROC) curve was used in evaluating the model’s prediction efficiency.
Results: Remarkable differences in age, duration of diabetes, presence or absence of hypertension, education level, exercise frequency and family monthly income were found among the patients (p < 0.001). Multivariate logistic regression analysis suggested age ≥60 (odds ratio (OR) = 3.395, 95% CI = 1.269–9.083), duration of diabetes ≥3 years (OR = 4.574, 95% CI = 1.623–12.885), presence of hypertension (OR = 4.011, 95% CI = 1.490–10.796), education level of junior high school and below (OR = 7.318, 95% CI = 3.648–14.678), no or little exercise (OR = 3.948, 95% CI = 1.989–7.839) and family monthly income <3500 yuan (OR = 2.871, 95% CI = 1.089–7.573) are risk factors for poor QOL (p < 0.05). The regression model was logit (p) = –5.412 + 1.222X1 + 1.520X2 + 1.389X3 + 1.990X4 + 1.373X5 + 1.055X6 (X1 as age ≥60, X2 as duration of diabetes ≥3 years, X3 as presence of hypertension, X4 as education level of below junior high school, X5 as no or little exercise and X6 as family monthly income <3500 yuan). Based on this model, the ROC curve showed that the AUC value, standard error and 95% CI were 0.842, 0.043 and 0.758–0.926, respectively. An analysis was made on the re-included 100 patients, and the predictive sensitivity, specificity and Kappa coefficient of the constructed model were 82.10%, 86.90% and 0.703.
Conclusions: Age ≥60, duration of diabetes ≥3 years, presence of hypertension, education level of junior high school and below, no or little exercise and family monthly income <3500 yuan were independent influencing factors for poor QOL in patients with T2DN. The use of this model has certain clinical application value.
Knowledge map
Save
Background: Based on publicly available transcriptome and single-cell sequencing data, the current study aimed to explore the molecular mechanisms underlying the involvement of hepatocellular carcinoma-derived growth factor-like 3 (HDGFL3) in prostate cancer (PCA) growth and metastasis.
Methods: The Gene Expression Omnibus database was used to download the single cell transcriptome of PCA (GSE193337). Single-cell RNA sequencing (scRNA-seq) data were examined to identify which genes are essential for endothelial cell function. The Cancer Genome Atlas Prostate Adenocarcinoma database provided the RNA sequencing data, and univariate COX regression analysis was introduced to identify the genes that were associated with the prognosis of patients with PCA. Human PCA cell lines PC-3 and DU145 were used in in vitro cellular studies to test the effect of silencing HDGFL3. The results were validated using Transwell® assay, scratch assay, and cell counting kit-8 assay. To support the role of HDGFL3 in PCA, an in vivo animal model of PCA transplantation tumor in nude mice was established. Quantitative reverse transcription polymerase chain reaction was introduced to measure HDGFL3 messenger ribonucleic acid (mRNA) expression levels in tumor tissues from nude mice, and Hematoxylin and Eosin staining was used to identify lung metastasis. Immunohistochemical staining was employed to identify the expression levels of HDGFL3 and hematopoietic progenitor cell antigen CD34+.
Results: It was discovered through analysis of the scRNA-seq dataset that HDGFL3, a gene specific to endothelial cells, is linked to a poor prognosis in men with PCA. In addition, HDGFL3 and the expression of genes linked to angiogenesis have a substantial association. Studies on cells in vitro revealed that silencing HDGFL3 prevented PC-3 and DU145 cells from proliferation, migrating and invading. Silencing HDGFL3 decreased the weight of prostate tumors, the number of lung metastases, and the area occupied by CD34+ vascular endothelial cells, according to in vivo investigations.
Conclusions: This study identified HDGFL3 as a key gene in endothelial cells that may stimulate tumor angiogenesis to increase the growth and spread of PCA. These results imply that HDGFL3 may represent a possible target for antiangiogenic therapy in the management of PCA.
Knowledge map
Save
Objective: To explore the effect of Kegel exercise combined with a therapeutic apparatus for electromyographic feedback on bladder function in patients with bladder injury during rehabilitation.
Methods: The clinical data of 156 patients with bladder injury admitted to Wuxi Medical Center of Nanjing Medical University in the past 2 years were selected for retrospective analysis. The patients were divided into the reference group (RG, Kegel exercise, n = 83) and the study group (SG, Kegel exercise combined with a therapeutic apparatus for electromyographic feedback, n = 73) in accordance with different rehabilitation programmes. The urination conditions and urodynamic indices of the SG and RG after intervention were compared, and patients’ mood states were evaluated with the hospital anxiety and depression scale (HADS).
Results: Compared with the RG, the SG had overtly lower bladder residual urine volume, daily urination frequency, detrusor pressure at the end of the filling period and detrusor leak-point pressure (all p < 0.001); Obviously higher urinary volume at each time and maximum bladder volume (all p < 0.001) and distinctly lower hospital anxiety and depression scale-anxiety (HADS-A) and hospital anxiety and depression scale-depression (HADS-D) scores after treatment (all p < 0.001).
Conclusions: The application of Kegel exercise combined with a therapeutic apparatus for electromyographic feedback during the rehabilitation of patients with bladder injury can effectively improve the urination conditions, bladder function and mood states of the patients. Moreover, it can guarantee the return to normal life of the patients and improve their quality of life.
Knowledge map
Save
Background: Nucleolar prominence is a biomarker of prostate cancer (CaP), and the nucleolar protein block of proliferation 1 (BOP1) participates in the development of CaP, which has great significance for CaP therapy. Thus, this study explored the mechanism of BOP1 in CaP development.
Methods: BOP1 expression levels in the tumor tissues of CaP patients and in PC3 tumor cells were determined. The viability, apoptosis rate of PC3 cells, and apoptosis-related proteins levels were determined to explore the effect of BOP1 on tumor-cell growth in vitro. BOP1 function in the metastasis of PC3 cells was further assessed by Transwell experiment. We also studied the influence of BOP1 on the expression of mitogen-activated protein kinase (MAPK) pathway-related proteins and investigated the regulatory effect of BOP1 on dual-specificity phosphatase 6 (DUSP6).
Results: BOP1 expression was upregulated in the tumor tissues and PC3 cells of CaP patients. BOP1 knockout reduced the activity of PC3 cells and induced apoptosis, significantly inhibiting the metastasis of PC3 cells. DUSP6 was overexpressed in tumor tissues and PC3 cells. BOP1 knockout inhibited DUSP6 expression and the MAPK pathway. DUSP6 overexpression reversed the inhibition of BOP1 siRNA (si-BOP1) on PC3 cells and the activated MAPK signaling pathway.
Conclusions: This finding demonstrated that BOP1 promoted CaP progression by regulating the DUSP6/MAPK pathway.
Knowledge map
Save
Background: Live surgery events (LSEs) are frequently organized for sharing the surgical experiences with surgeons at the beginning of their learning curves. The aim of this study was to investigate whether the outcomes and complication rates of patients underwent retrograde intrarenal surgery (RIRS) at LSEs are comparable with regular cases.
Methods: Ten courses were organized during 2017–2022. Data of 32 patients who operated in the LSEs were 1:3 matched (for stone burden and surgeon) with the data of patients who underwent regular RIRS within the course periods at the same centers (n = 96). All courses took place in concordance with the latest LSE policies. The primary outcomes were stone-free and complication rates. Fluoroscopy and operation times were the secondary outcomes.
Results: Stone-free rates of the groups were similar (84% in LSE and 79% in control group; p = 0.520). Similarly, there were no differences in complication rates (p = 0.428) and fluoroscopy time (p = 0.477). Duration of the LSE cases (82.24 ± 31.12 min) was slightly but insignificantly longer than regular cases (73.77 ± 20.89 min, p = 0.092). Moreover, guest surgeons tend to have longer operation time with statistically insignificant prolongation (74.92 ± 30.43 min for host, 89.52 ± 28.34 min for guest surgeons, p = 0.064).
Conclusions: RIRS can be performed without jeopardizing operation efficiency and patient safety in LSEs. If surgeon is not familiar with operating room set-up or staff, live surgery must be performed by host surgeon to avoid extended operating time.
Knowledge map
Save
Objective: This study aimed to explore the clinical effect of electrical acupoint stimulation with low-frequency pulse in the treatment of urinary incontinence after prostatectomy.
Methods: This study selected 104 patients who underwent radical prostatectomy in Pujiang People Hospital from April 2019 to April 2022 as the research subjects, and they were divided into the study group (SG, n = 51, electrical acupoint stimulation with low-frequency pulse) and the control group (CG, n = 53, traditional pelvic floor muscle exercise) in accordance with the therapeutic regimen. In addition, clinical and follow-up data were analysed, and the number of urine pads used before and after treatment, recovery time of urinary continence, scores of 36-Item Short-form Health Survey (SF-36), clinical curative efficacy and incidence of adverse reactions in both groups were compared.
Results: Before treatment, no remarkable difference in the number of urine pads used was observed between the two groups (p > 0.05). After treatment, the number of urine pads used in the two groups was less than that before treatment, and the number of urine pads used in the SG was less than that in the CG (p < 0.001). The SG had overtly shorter recovery time of urinary continence, higher scores in eight dimensions of SF-36 and higher treatment efficiency than the CG (all p < 0.05), with no remarkable difference in the incidence of adverse reactions in both groups (p > 0.05).
Conclusions: Electrical acupoint stimulation with low-frequency pulse, as a safe and ideal treatment, can shorten the recovery time of postoperative urinary continence ability, reduce the incidence of urinary incontinence and improve the quality of life of patients.
Knowledge map
Save
Objective: The expression of vascular endothelial growth factor-A (VEGF-A) in snakebite patients, its value in patient prognosis and the correlation of VEGF-A with renal function were analysed.
Methods: A total of 124 snakebite patients admitted from January 2019 to January 2021 were retrospectively analysed and included in the observation group, and 40 healthy individuals who underwent physical examination in the same hospital within the same period were included in the control group. The t-test was used in analysing differences between the serum VEGF-A levels of the observation and control groups and changes in VEGF-A and renal function indices before and after treatment in the observation group. The effects of treatment on each patient in the observation group were evaluated, and the patients were divided into improved and unimproved groups according to the post-treatment condition. The predictive value of VEGF-A and renal function indices in patients in the improved and unimproved groups and their efficacy for snakebite patients were analysed through receiver operating characteristic (ROC) analysis. Finally, correlation analysis was used in evaluating the correlation between VEGF-A and renal function indices.
Results: VEGF-A was significantly higher in patients in the observation group (339.66 ± 97.72 pg/mL) than in patients in the control group (52.41 ± 8.93 pg/mL; p < 0.001). VEGF-A and renal function indices in the serum of patients were significantly lower after treatment than those before treatment (p < 0.0001). According to efficacy, the patients were divided into improved group (n = 102) and unimproved group (n = 22). The pre-treatment VEGF-A levels were significantly lower in patients in the improved group (318.47 ± 90.80 pg/mL) than in patients in the unimproved group (437.88 ± 63.16 pg/mL; p < 0.001). ROC curve analysis revealed that the area under the curve for VEGF-A in predicting patient treatment efficacy was 0.886, and VEGF-A was positively correlated with blood urea nitrogen, creatinine and cystin C but negatively correlated with glomerular filtration rate (p < 0.001).
Conclusions: VEGF-A was highly expressed in snakebite patients and can be used as an observational indicator for predicting the prognosis of snakebite patients.
Knowledge map
Save
Background: Clear cell renal cell carcinoma (ccRCC) constitutes the most frequently encountered sporadic class of kidney cancer in adults. Recently, a rare form of clear cell kidney cancer known as ccRCC with hemangioblastoma-like features was proposed, with unique immunological characteristics and a good prognosis. The tumor expressed alpha-inhibin and carbonic anhydrase Ⅸ (CA9) as examined by immunohistochemistry.
Methods: Herein, we report a clinical instance of ccRCC with hemangioblastoma-like features. A 49-year-old woman presenting with a chief complaint of hematuria underwent a comprehensive and meticulous assessment. Imaging findings indicated the presence of a mass in the right kidney. Subsequently, she underwent a partial nephrectomy.
Results: Histopathological analysis of the resected specimen confirmed the presence of ccRCC with hemangioblastoma-like features. The patient was discharged from the hospital six days post-surgery and could resume her daily activities. During a one-year follow-up after surgery, no signs of recurrence were detected.
Conclusions: This case demonstrates the importance of including ccRCC with hemangioblastoma-like features in the differential diagnosis of renal masses in patients with hematuria, and suggests partial nephrectomy as an effective treatment modality for this rare subtype of renal cell carcinoma. However, because of the small number of reported cases and insufficient follow-up time, further investigation is necessary to determine the optimal therapeutic approach and to identify the molecular and genetic characteristics of this tumor.
