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Background: Physical activity (PA) is a safe and feasible intervention for prostate cancer (PCa) patients undergoing radiotherapy (RT) and may improve cancer-related fatigue, physical function, and quality of life (QoL). However, evidence specifically addressing PA delivered during RT and the biological mechanisms supporting potential radiosensitisation or normal-tissue protection remains heterogeneous.
Methods: We conducted a narrative review of studies published in the last 10 years evaluating PA interventions in men receiving RT for PCa or in survivors previously treated with RT, focusing on feasibility/adherence, safety, treatment-related toxicity, physical function, body composition/metabolic outcomes, and patient-reported QoL.
Results: Supervised PA, both cardiovascular and strength-based, is safe and feasible during RT, with high adherence and low risk. Across trials, PA is associated with reduced short-term fatigue, better maintenance of muscle mass and physical performance, and improved QoL, including in men receiving concomitant androgen deprivation therapy. Evidence suggesting positive effects on urinary and bowel symptoms and the therapeutic index is emerging, although mechanistic data in humans during RT are limited and largely indirect.
Conclusions: Current evidence supports integrating structured, individualised PA as an adjunct to RT for PCa, given its consistent functional and quality-of-life benefits and favourable safety profile. Future trials should standardise PA dose and outcomes and further clarify dose–response relationships and biological mechanisms during RT.
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Background: Three-dimensional (3D) imaging is used for preoperative planning of partial-nephrectomy, enhancing visualisation of tumour anatomy, vascular structures, and their spatial relationships. This systematic review evaluated the impact of 3D-assisted planning on surgical, perioperative, and functional outcomes in adults undergoing partial-nephrectomy.
Methods: A systematic review was conducted according to PRISMA 2020 guidelines. Eligible studies included adults with clinically localised T1–T2 renal tumours undergoing open, laparoscopic, or robotic partial-nephrectomy, in whom preoperative 3D reconstructions from CT or MRI were compared with conventional two-dimensional planning. Outcomes assessed were positive surgical margins, warm-ischaemia time, postoperative complications, renal function, operative time, estimated blood loss, and hospital stay. Searches of MEDLINE, EMBASE, Cochrane CENTRAL and Web of Science (2015–2025) identified 495 records; after screening and assessment, 9 studies were included.
Results: Nine studies reported surgical and functional outcomes of partial-nephrectomy using 3D technology. Positive surgical margin rates were 0–9%, with only one study demonstrating a significant difference favouring the 3D cohort (0% vs 28%). Renal function outcomes were generally comparable, although one study reported superior eGFR preservation in the 3D cohort (80% vs 70% of baseline; p = 0.02). Warm-ischaemia time ranged from 13.5 to 26 minutes, with a significant reduction reported only by one study (24 vs 28 min; p < 0.01). Operative time showed variations across studies (ranging from 105-212 minutes), with two studies showing significant reductions (e.g., 130 vs 160 min; p < 0.05). Estimated blood loss ranged from 50 to 830 mL, and two studies demonstrated significant reductions with 3D imaging (e.g., 591 vs 141 mL; p = 0.019).
Conclusions: Available evidence suggeststhat 3D-assisted preoperative planning may be associated with improvementsin selected perioperative outcomes, namely operative time, blood loss, and warm-ischaemia time, while maintaining low positive-margin rates and without increasing postoperative complications or impairing renal function. However, findings are inconsistent and based predominantly on non-randomised studies with small-sample sizes and methodological heterogeneity. Larger prospective studies with standardised outcome reporting are required to possibly define with more accuracy the clinical benefits of 3D planning in partial-nephrectomy.
The PROSPERO Registration: CRD420251160851. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID= 1160851
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Background: Androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPIs) improve advanced prostate cancer (PCa) outcomes but increase cardiovascular (CV) toxicity, making cardiovascular disease (CVD) a major competing cause of morbidity, and mortality. To review the current evidence on CV toxicity related to ADT and ARPIs in PCa focusing on the magnitude of CV risk, strategies for CV risk assessment and prevention in clinical practice.
Methods: A narrative review of the English-language literature was conducted using PubMed, Scopus, the Cochrane Library, and ScienceDirect. The search included studies through December 2025 on ADT- and ARPI-associated cardiovascular toxicity. Search terms combined keywords and Medical Subject Headings (MeSH) terms such as “prostate cancer”, “androgen deprivation therapy”, “androgen receptor pathway inhibitors”, “cardiovascular toxicity”, and “cardio-oncology”. Eligible studies included prospective clinical trials, systematic reviews, meta-analyses, and clinically relevant retrospective or real-world studies. Reference snowballing was not performed.
Results: ADT induces metabolic, vascular, inflammatory, and endocrine alterations that promote a proatherogenic and prothrombotic state. CV risk appears to vary across hormonal therapies. Gonadotropin-releasing hormone (GnRH) antagonists appear to be associated with lower early rates of major adverse cardiovascular events (MACE)—as defined in each included study—than GnRH agonists, particularly in patients with pre-existing CVD, although evidence from meta-analyses and realworld studies remains heterogeneous. ARPIs show distinct CV safety profiles, with higher rates of hypertension and CV events reported with abiraterone and apalutamide, whereas darolutamide appears to have a more favorable profile.
Conclusions: Systematic CV risk assessment, preventive management of modifiable risk factors, and individualized treatment strategies within a multidisciplinary cardio-oncology framework are essential to optimize long-term outcomes in patients with PCa receiving ADT and ARPIs.
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Background: Involuntary urine loss, also known as urinary incontinence (UI), commonly affects women as a result of pelvic floor weakness or bladder malfunction. Despite conflicting and inconclusive data, pelvic floor muscle training (PFMT) is frequently used to treat individuals with stress urinary incontinence (SUI). This study was designed to investigate the effectiveness of PFMT in females with SUI.
Methods: PubMed, the cochrane library, embase, science direct, web of science, scopus, and google scholar databases were searched until 31st October 2023.Included peer reviewed randomized controlled trials (RCTs) published in English language that assessed effect of PFMT in stress-related UI. The I 2 test and a funnel plot were used to analyze heterogeneity and publication bias. Risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist. Random-effects meta-analysis was performed. Results: 14 publications, primarily RCTs, were selected from 8440 citations for the final qualitative analysis. Articles were published between 2010 and 2023, with 2192 total participants ranging from 30 to 600 and aged 18–80 were included. PFMT shows 14% absolute reduction in UI (risk difference (RD) = 0.14; 95% confidence interval (CI): 0.04–0.25; p = 0.01) and significantly improved quality of life (QoL) (RD = 0.17; 95% CI: 0.06–0.29; p < 0.01). Substantial heterogeneity was explored through subgroup and sensitivity analyses.
Conclusions: This meta-analysis showed that PFMT reduces UI and improves the QoL in women. The PROSPERO registration: The study was registered at Clinicaltrials.gov (https://www.crd.york.ac.uk/PROSPERO/view/C RD420261339337), registration number: CRD420261339337.
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Background: Active surveillance (AS) is a well-established strategy for managing prostate cancer (PCa); however, available evidence indicates that approximately 28% of patients may experience progression within the first 5 years. Magnetic resonance imaging (MRI) may help optimize patient selection. This study assessed whether the presence of focal lesions (prostate imaging reporting and data system (PI-RADS) ≥ 3) on baseline MRI is associated with an increased risk of histological progression and AS discontinuation.
Methods: We conducted a retrospective study of consecutive patients enrolled in AS at a comprehensive cancer center since 2012, recorded in the Urodata platform, based on a prospectively maintained cohort and including patients meeting European Association of Urology (EAU) criteria for low- or favorable intermediate-risk PCa. Inclusion criteria were diagnostic and confirmatory transperineal biopsies performed with the institution’s standard technique, available baseline MRI, and a minimum follow-up of one year. Patients with prior treatment were excluded. Histological progression was defined as an increase in Gleason grade group on follow-up biopsy compared with baseline. Progression at 5 years was evaluated using Kaplan-Meier curves and multivariable Cox proportional hazards models. Patients with PI-RADS ≥ 3 were classified as visible lesions on MRI (MRI+), and those with PI-RADS <3 as no visible lesions on MRI (MRI-).
Results: A total of 105 patients were included, with a median age of 64 years (interquartile range (IQR) 59–70) and a median prostate-specific antigen (PSA) of 5.8 ng/mL (IQR 4.7–8.9). The median interval between initial and confirmatory biopsy was 24 months, and median follow-up was 6 years. Seventy-one patients were classified as MRI+. Baseline characteristics were similar between groups. Five-year progression-free survival was 41% in MRI+ versus 77% in MRI- groups ( hazard ratios (HR) 5.5; 95% confidence interval(CI) 2.3–13). Only 28% of patients with PI-RADS 5 remained free of progression at 5 years. Baseline PSA >6 ng/mL and PSA density >0.2 were independently associated with histological progression.
Conclusions: The presence of PI-RADS ≥ 3 lesions on baseline MRI is significantly associated with an increased risk of histological progression and AS discontinuation. MRI may be a key tool for optimizing candidate selection for AS.
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Background: Muscle-invasive bladder cancer (MIBC) presents a heterogeneous response to perioperative chemotherapy. Although several molecular classifications of MIBC have been proposed, two main subtypes, namely, luminal and basal, are widely recognised. This study aims to explore the relationship between the molecular subtypes of MIBC, as characterised by GATA binding protein 3 (GATA3) and cytokeratin 5/6 (CK5/6) immunohistochemistry, and treatment response to neoadjuvant chemotherapy.
Methods: Patients with nonmetastatic MIBC who were treated with cisplatin-based neoadjuvant chemotherapy at the Reina Sofía University Hospital between 2014 and 2023 were retrospectively analysed. Tumours were classified into luminal (GATA3+, CK5/6–), basal (GATA3–, CK5/6+), double-positive (GATA3+, CK5/6+), or double-negative (GATA3–, CK5/6–) subtypes. Clinical and pathological data, including overall survival (OS), disease-free survival (DFS) and pathological response, were analysed by using Kaplan–Meier curves, log-rank tests and chi-squared tests.
Results: Amongst the 69 patients included, 13 were classified as luminal, five as basal, 50 as double positive and one as double negative. Patients with luminal tumours had significantly higher five-year DFS (91.7% vs. 50.7%, p = 0.021) and OS (100% vs. 60.5%, p = 0.016) than those with double-positive tumours. Pathological complete response (ypT0) was observed in 7/13 (53.8%) luminal tumours and in 15/50 (30.0%) double-positive tumours (p = 0.190). Additionally, 9/13 (69.2%) luminal tumours achieved tumour downstaging (<ypT2), whereas 20/50 (40.0%) double-positive tumours (p = 0.060) achieved tumour downstaging. Basal and double-negative subtypes were excluded from analysis because of their low representation in the sample.
Conclusions: The luminal subtype showed superior outcomes in terms of DFS and OS compared with double-positive tumours. Higher rates of pathological complete response and tumour downstaging were observed in luminal tumours than in other tumour types. However, these differences did not reach statistical significance.
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Background: Sacrocolpopexy is the gold standard for multicompartimental pelvic organ prolapse (POP). Patients with associated perineal descent presents higher recurrence rates. To address this, we developed the Integral Perineal Sacrocolpopexy (IPSC), a modification designed to increase anterior reinforcement through extended anterior dissection and mesh fixation to the levator ani muscles.
Methods: In addition to describing the Integral Perineal Sacrocolpopexy technique, we prospectively analyzed a case series of 15 patients with POP and magnetic resonance imaging (MRI)-confirmed perineal descent, treated between October 2018 and January 2024.
Results: The cohort had a median age of 71 years and seven patients had a prior hysterectomy with concomitant prolapse repair. Mean operative time was 145 minutes and median hospital stay was 2 days. No postoperative complications or hospital readmissions occurred. At a median follow-up of 48 months, anatomical success was achieved in all patients. Regarding urinary function, urgency incontinence improved substantially, whereas stress incontinence persisted in one patients and occurred de novo in four. One patient developed late intravesical mesh erosion, treated endoscopically without recurrence.
Conclusions: Integral Perineal Sacrocolpopexy appears to be a safe and feasible technique for highly selected patients with compromised pelvic floor support, offering anatomical and functional correction with a complication profile within the range reported for conventional sacrocolpopexy.
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Background: This study investigated the association between computed tomography (CT) features and fatty acid-binding protein 2 (FABP2) gene expression in clear cell renal cell carcinoma (ccRCC), focusing on morphologic and metabolic parameters. Methods: A retrospective analysis was performed on 246 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA). Patients were classified as FABP2-positive (n = 57, 23.17%) or FABP2-negative (n = 189, 76.83%). Clinical, pathological, and imaging features were compared. Quantitative CT assessed mean tumor attenuation and abdominal adipose compartments. Two logistic regression models were built: one based on radiologic features and one on metabolic imaging parameters.
Results: FABP2-positive tumors were significantly smaller, more frequently low-grade and diagnosed at an earlier stage. FABP2 expression was more common in male patients. On imaging, FABP2-negative tumors more often exhibited collateral vascular supply. Quantitative CT revealed lower mean attenuation in FABP2-positive tumors, suggesting higher intracellular lipid content. No significant differences were found in hepatic attenuation or abdominal adipose compartments. The radiologic model achieved an area under the curve (AUC) of 0.58, with cystic composition as the strongest predictor of FABP2 positivity. The lipid metabolism-based model showed slightly better performance (AUC 0.61), with mean tumor attenuation as the most influential variable.
Conclusions: FABP2-positive ccRCC appears to represent a less aggressive, lipid-rich phenotype. CT attenuation features were weakly associated with FABP2 expression and may offer preliminary, noninvasive insights to support integrated radiogenomic approaches in ccRCC.
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Background: We aim to evaluate the co-occurrence of prostate cancer (Pca) and bladder cancer (Bca). We also aim to identify their clinicopathological characteristics and oncological outcomes in accordance with their status as either synchronous or metachronous during oncological follow-up.
Methods: Retrospective data query set to the timeline of 2011–2022 yielded 72 patients with synchronous or metachronous Pca and Bca from the hospital database. Patients with synchronous cancers were assigned to group I, those with metachronous Bca after Pca were assigned to group II and those with metachronous Pca after Bca were assigned to group III.
Results: The synchronous group included 33 (45.83%) patients, whereas the metachronous group included 39 (54.17%) patients (29 patients (40.28%) in group II and 10 (13.89%) in group III). The rate of high-grade Bca (71.88%) and presence of carcinoma in situ (CIS) (46.87%) were higher in synchronous tumours than in other tumour types. 5- and 10-year overall and metastasisfree survival rates were lower in the synchronous group than in the metachronous groups. The 10-year survival rates for all three groups were 61%, 89% and 91%. In all groups, the lung was the most common metastatic site and the third most common cancer site.
Conclusions: The survival rate in the synchronous group was lower than that in the metachronous groups. In addition, the risk of a third tumour is high in patients with synchronous or metachronous tumours. The occurrence of lung cancer as the third most common tumour in these patients might be related to the common habit of smoking.
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Background: To evaluate the correlation between age and prostate pathological outcomes obtained through systematic transrectal prostate biopsy in 50- to 80-year-old patients with prostate-specific antigen levels ranging from 2.5 to 25 ng/mL.
Methods: This retrospective study included 1079 patients aged 50–80 years who underwent transrectal ultrasound-guided prostate biopsy. The patients were divided into two primary age groups: 50–65 years and 66–80 years. Additionally, the patients were stratified into six 5-year age subgroups (50–55, 56–60, 61–65, 66–70, 71–75, and 76–80 years). Pathological outcomes were compared between these primary age groups and subgroups.
Results: The prostate cancer detection rate increased from 27.6% in patients aged 50–65 years to 46.4% in those aged 66–80 years (p = 0.001). Clinically significant prostate cancer was more frequent in patients older than 70 years. The International Society of Urological Pathology (ISUP) grade groups 3 and 4 were significantly more common in patients aged 76–80 years than in those under 70 years (p = 0.001). No significant differences were observed for the ISUP grade groups 2 and 5. For grade group 1, a significant difference was found only between the 61–65 and 66–70-year age groups.
Conclusions: This study revealed that the detection rates of clinically significant prostate cancer and higher ISUP grade groups (especially grades 3 and 4) increased notably after age 65 years. These findings highlight the importance of age-adjusted risk assessment and individualized prostate-specific antigen screening and biopsy strategies. Further prospective studies are needed to refine protocols for older patients.
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Background: This study aims to evaluate the frequency of overactive bladder syndrome (OAB) and its relationship with disease activity in patients diagnosed with axial spondyloarthritis (axSpA).
Methods: The study included 127 axSpA patients and 110 healthy individuals meeting age and gender criteria were included in the study. The demographic data, laboratory results, and clinical parameters of the groups were recorded and compared. axSpArelated disease activity was assessed with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS), functional status with the Bath Ankylosing Spondylitis Functional Index (BASFI), quality of life with the AS Quality of Life Questionnaire (ASQoL), and OAB-related symptoms with the Overactive Bladder Questionnaire Version 8 (OAB-V8).
Results: In the axSpA patient group, the incidence of OAB was 34.6% (n = 44), the mean and standard deviation OAB-V8 score was 8 ± 11, while in the control group it was 10.9% (n = 12) and the mean and standard deviation score was 4 ± 5 (p < 0.001, p < 0.001). According to BASDAI, ASDAS-C-reaktive protein (ASDAS-CRP), and ASDAS-erythrocyte sedimentation rate (ASDAS-ESR) results, the differences in OAB-V8 scores between the patients with high and low disease activity were found to be significant (p = 0.007, p = 0.039, p = 0.013). A significant difference was found in ASDAS-ESR (p = 0.04), BASDAI (p = 0.003), and BASFI (p = 0.01) scores between patients with OAB symptoms compared to those without OAB symptoms. A significant correlation was observed between the patients’ OAB-V8 score and BASDAI (p < 0.001), ASDAS-CRP (p < 0.001), ASDAS-ESR (p < 0.001), BASFI (p < 0.001) scores. It was determined that the quality of life of axSpA patients with OAB symptoms was negatively affected (p < 0.001).
Conclusions: The frequency of OAB was higher in axSpA patients than in the control group and showed significant associations with disease activity, functional impairment, and quality of life parameters.
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Background: This study aimed to comparatively examine digital search behaviors related to urological symptoms and conditions in Türkiye, the United States, Germany, the United Kingdom, India, and Japan using Google Trends data.
Materials and Methods: This cross-sectional, observational digital epidemiology study analyzed weekly web search data from the past five years obtained via the Google Trends platform. Ten urological conditions were evaluated: kidney stones, benign prostatic hyperplasia, dysuria, urinary incontinence, erectile dysfunction, premature ejaculation, varicocele, testicular pain, infertility, and penile curvature. Mean Google Trends scores were used for cross-country comparisons, while country-specific digital search profiles were normalized to reflect relative distributions. Searches related to kidney stones were additionally analyzed for seasonal variation. K-means clustering analysis was applied to identify similarities in digital search profiles across countries.
Results: Kidney stones were identified as the urological condition with the highest digital search interest in all countries, with increased search activity observed during the summer months. Benign prostatic hyperplasia and dysuria were among the most frequently searched conditions across all countries. Searches related to reproductive and sexual health showed considerable variation between countries. Clustering analysis revealed that the United States, Germany, and the United Kingdom shared similar digital search profiles, whereas India and Japan formed a distinct cluster. Türkiye demonstrated a profile broadly similar to Western countries but with partial divergence.
Conclusions: Digital search behaviors related to urological symptoms and conditions exhibit heterogeneous patterns across countries. Google Trends data may serve as a complementary tool for assessing population-level urological health awareness.
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Background: This study investigated the quality and comprehensibility of responses generated by four different artificial intelligence (AI)-powered chatbots (ChatGPT, Gemini, DeepSeek, and Grok) when queried about testicular prostheses.
Methods: A Google search using the keyword “testicular prosthesis” was conducted, and the 50 most frequently asked questions listed in the “People Also Ask” section were identified. These questions were categorized into preoperative, perioperative, and postoperative topics and were posed to four AI chatbots: ChatGPT, Google Gemini, DeepSeek, and Grok. The responses were independently evaluated by four urologists using the Global Quality Scale (GQS), Modified DISCERN, and Patient Education Materials Assessment Tool for Printed Materials (PEMAT-P) scales to assess quality, reliability, and readability.
Results: According to the GQS evaluation, the median scores for ChatGPT, Gemini, DeepSeek, and Grok were 4.75, 4.5, 4.75 and 4.875, respectively (p < 0.001). According to the Modified DISCERN scale, the scores were 2.75, 3.0, 3.75 and 3.0, respectively. The PEMAT-P understandability scores were 79.1%, 75.0%, 84.2% and 78.6%, respectively (p < 0.001). Similarly, the PEMAT-P actionability scores were 73.5%, 68.5%, 78.9% and 73.2%, respectively (p < 0.001).
Conclusions: While all chatbots provided high-quality responses, their reliability was moderate. DeepSeek demonstrated the best performance across the evaluated metrics. These findings suggest that AI chatbots may serve as useful supplementary tools for patient education regarding testicular prostheses.
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Background: Systemic treatment options for locally advanced or metastatic urothelial carcinoma (La/mUC), especially for patients resistant to chemotherapy and ineligible for immunotherapy, are a current research focus. Enfortumab vedotin (EV), an antibody-drug conjugate targeting Nectin-4, has recently been introduced, necessitating attention to its potential adverse reactions for patient safety.
Methods: Databases were searched for publications up to 12 June 2025. Clinical trials and retrospective studies investigating EV therapy were included in the analysis. Adverse reactions and complications were primary outcomes, analyzed using Stata 14.0. Results: 22 studies (including 3 randomized controlled trials (RCTs)) with 1715 patients were included. The most common adverse effect was fatigue (38.41%, 95% confidence interval [CI]: 31.10%–45.99%, I 2 = 85.2010, p < 0.001). Other common effects included rash, alopecia, peripheral sensory neuropathy, pruritus, dysgeusia, decreased appetite, and decreased weight, and the pooled incidence was 37.20% (95% CI: 30.45%–44.21%, I 2 = 86.2369, p < 0.001), 37.14% (95% CI: 30.15%–44.40%, I 2 = 79.0839, p < 0.001), 33.68% (95% CI: 29.44%–38.06%, I 2 = 59.0190, p = 0.0011), 30.24% (95% CI: 21.26%–40.01%, I 2 = 91.4944, p < 0.001), 27.50% (95% CI: 20.69%–34.87%, I 2 = 83.9947, p < 0.001), 27.17% (95% CI: 18.46%–36.81%, I 2 = 90.4200, p < 0.001) and 26.55% (95% CI: 20.16%–33.45%, I 2 = 0.0000, p = 0.8935), respectively. The average pooled incidence of grade ≥ 3 adverse events was below 7.0%, with severe complications like rash 6.99% (95% CI: 4.97%–9.28%, I 2 = 45.9297, p = 0.0267), anemia 5.53% (95% CI: 3.03%–8.60%, I 2 = 56.9147, p = 0.0132), and neutropenia 4.95% (95% CI: 3.35%–6.80%, I 2 = 6.7786, p = 0.3788).
Conclusions: EV offers a new second-line treatment for La/mUC after chemotherapy and immunotherapy failures. It shows a generally manageable safety profile. However, severe adverse events such as skin complications, peripheral neuropathy, hyperglycemia, fatigue, and decreased appetite require attention. Given the low quality of some included studies, further evidence from larger-scale studies is needed to confirm its long-term tolerability.
PROSPERO registration number: The systematic analysis was conducted according to the guidelines of the PRISMA statement and registered on PROSPERO (CRD42022273772). (https://www.crd.york.ac.uk/PROSPERO/view/CRD42022273772)
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Background: To investigate the effects of perioperative continuity nursing care on urinary function recovery, improvement in lower urinary tract symptoms, and postoperative complications in patients after transurethral resection of the prostate (TURP). Methods: We analysed the medical records of 193 patients with benign prostatic hyperplasia who underwent TURP at Jieshou People’s Hospital between January 2023 and June 2024. Based on the perioperative care regimens actually administered to the patients, they were divided into a control group (n = 95) and a study group (n = 98). Data were collected and compared regarding patients’ recovery of urinary function, improvement in lower urinary tract symptoms, inflammatory markers, and postoperative complications.
Results: The time to return of spontaneous voiding (TRSV) was significantly shorter in the study group than in the control group; post-void residual volume (PVR) at three months postoperatively was significantly lower in the study group than that in the control group; maximum flow rate (Qmax) was significantly higher in the study group than that in the control group; and the use of 24-hour urine pads at three months postoperatively was significantly less in the study group than that in the control group. At three months post-operatively, the International Prostate Symptom Score (IPSS) in the study group was significantly lower than that in the control group. Five days post-operatively, C-reactive protein (CRP) levels in the study group were significantly lower than those in the control group. The overall incidence of post-operative complications in the study group was 4.49%, which was significantly lower than the incidence (13.48%) observed in the control group.
Conclusions: Perioperative continuity nursing care is associated with improved postoperative urinary function, alleviated lower urinary tract symptoms, reduced postoperative inflammatory response and a lower risk of complications in patients undergoing TURP.
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Objective: This study aimed to investigate the clinical efficacy of negative pressure suction combined with flexible ureteroscopic holmium laser lithotripsy (FUHLL) for treating infectious renal calculi and its effect on perioperative inflammatory indicators. Methods: A total of 150 patients with infectious renal calculi admitted to our Department of Urology from January 2023 to December 2025 were retrospectively selected and divided into an observation group (79 cases) and a control group (71 cases) based on the surgical methods used. After propensity score matching, 126 valid cases were finally included, with 63 cases in each group. The control group received conventional digital FUHLL, while the observation group received additional negative pressure aspiration. Perioperative indicators, stone clearance rate, inflammatory indicators at different time points and postoperative complications were compared between the two groups.
Results: The observation group had significantly shorter operation duration, postoperative bed rest time, and hospital stay time than the control group (p < 0.05). The stone clearance rate at 4 weeks postoperatively was 93.65% in the observation group, significantly higher than the 85.71% in control group (p < 0.05). At 6, 24, and 72 hours after surgery, levels of inflammatory indicators in the observation group were significantly lower than those in the control group (p < 0.05). The total postoperative complication rate was 4.76% in the observation group, significantly lower than the 20.63% in the control group (p < 0.05). Maximum stone diameter was identified as an independent risk factor for postoperative complications (OR = 16.923, 95% CI: 1.985–144.325, p = 0.010).
Conclusions: Negative pressure suction combined with digital flexible ureteroscopic holmium laser lithotripsy effectively improves stone removal efficiency and shorten operation and recovery time.
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Background: This study aimed to investigate the effects of evidence-based nursing-guided optimization of disinfection supply processes on postoperative infection prevention and patient recovery after surgery for ureteral calculi.
Methods: This single-centre retrospective study included 122 patients who underwent ureteral calculi surgery in our hospital between March 2023 and March 2025. Based on the disinfection supply management model used, we divided patients into a control group (routine disinfection supply process) and a study group (evidence-based nursing-guided process optimization). The two group were compared for surgical-related indicators, postoperative recovery outcomes, infection-related outcomes, and inflammatory markers (white blood cell count [WBC], neutrophil percentage [NE], C-reactive protein [CRP] and procalcitonin [PCT]) measured on postoperative days 1 and 5.
Results: No statistically significant differences were observed between the two groups in baseline characteristics or operative duration (p > 0.05). Similarly, no statistically significant differences were found in surgeon experience, operative duration, intraoperative irrigation pressure, or ureteral stent placement (p > 0.05). The incidence of urinary tract infection and surgical site infection was significantly lower in the study group than in the control group (p < 0.05), while no significant differences were found in postoperative fever or urine culture positivity rates (p > 0.05). On postoperative day 1, no significant differences were identified in inflammatory markers between the two groups (p > 0.05); however, on postoperative day 5, levels of WBC, NE, CRP, and PCT were significantly lower in the study group than in the control group (p < 0.05).
Conclusions: Evidence-based nursing-guided optimization of disinfection supply processes was associated with lower postoperative infection rates, reduced inflammatory marker levels, and improved postoperative recovery in patients with ureteral calculi, suggesting clinical value for perioperative infection prevention and control.
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Background: Cystitis glandularis (CG) frequently coexists with pelvic lipomatosis (PL). However, the simultaneous presence of a single-system ectopic ureter (SSEU) has not been previously documented. This anatomical triad results in unusual bladder anatomy and obscured ureteric orifices, potentially increasing the risk of postoperative ureteric obstruction following transurethral resection procedures.
Methods: Three patients with confirmed comorbid CG and PL (CG/PL) underwent transurethral resection of cystitis glandularis (TUR-CG) for persistent lower urinary tract symptoms. An SSEU was identified intraoperatively in all cases. Postoperative imaging and clinical outcomes were reviewed, with particular emphasis on the risk of hydroureteronephrosis. Informed consent was obtained from all patients.
Results: All patients developed new-onset hydroureteronephrosis within months of TUR-CG despite normal preoperative uppertract imaging. Two required ureteric reimplantation owing to recurrent infection or stent-related stricture. The coexistence of CG, PL, and SSEU resulted in concealed or non-orthotopic ureteric orifices. This increased the likelihood of inadvertent orifice involvement during TUR-CG and complicated subsequent reconstructive surgery.
Conclusions: CG/PL, when complicated by unrecognised SSEU, represents a high-risk anatomical configuration in which TURCG may precipitate premature ureteric obstruction. Thorough preoperative imaging, surgical awareness of aberrant ureteric anatomy, careful consideration of surgical indications, and patient counselling are essential for minimising postoperative hydroureteronephrosis and anticipating technical challenges during subsequent ureteric reconstruction.
