The major goal of prostate cancer imag-ing in the next decade will be more accurate disease di-agnostic, characterization and staging through the syn-thesis of anatomic, functional and molecular imaging. Changes are happening regarding the use of prostate MRI for evaluating primary prostate cancer and PET CT for the staging and recurrence staging of prostate can-cer. This review presents a multidisciplinary perspective of the role of prostate MRI and molecular imaging in prostate cancer.