
TISSUE ENGINEERING IN URETHRAL RECONSTRUCTION
Tao Cui, Ryan Terlecki, Anthony Atala
TISSUE ENGINEERING IN URETHRAL RECONSTRUCTION
Urethral strictures are one of the mostcommon urological problems, yet the natural limitationsof wound healing and the physiologic demands on theanatomic structures combine to also make urethral stric-tures one of the most challenging urological problems tomanage. Proper wound healing demands well approxi-mated edges because prolonged inflammation andgranulation, required to close large, deep wounds, willresult in excess collagen production, fibrosis, and theformation of a scar or, in the urethra, a stricture. Bioma-terials have successfully been used to approximate theECM of several different tissue types and can define athree dimensional space suitable for the formation of newtissues with both appropriate structure and appropriate function. Biomaterials can be broadly categorized as ei-ther synthetic polymers or tissue matrices, each with theiradvantages and limitations. Recent studies utilizing cellseeded natural biomaterials in urethral repair has yiel-ded some promising results. However, advancements inthe use of alternative sources of cells for matrix seedingand cell-seeded synthetic materials hold the possibility ofeven better results in the future
Urethral repair / Biomaterials / Wound healing / Tissue Matrices / Urethral surgery {{custom_keyword}} /
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