OBJECTIVE: Thirty cases ofadrenalectomy are presented. The diagnostic andtherapeutic aspects of adrenal disease are reviewed.METHODS: Over the last 6 years, 30 adrenalectomieswere performed in 28 patients (20 females and 8 males)aged 16 - 83 years (mean age 51 years). The lesion wasincidentally discovered in 18.5%, 33.3% presented abdominalor lumbar pain, 18.5% had Cushing’s syndrome,18.5% presented headache and hypertension, and 7.4%virilization.Diagnostic evaluation included laboratory studies,ultrasound and CT assessment. Scintigraphic localizationwith MIBG, MRI or arteriography was performed inspecific cases. The flank approach was utilized in 53% ofthe cases.RESULTS: The postoperative period ranged from 7-23days (mean 11). Postoperative complications (38.4%)following adrenalectomy were splenectomy, hemorrhage,hypertensive episodes, vascular complications, woundinfection and pneumonia. Fifty percent of the masses were pheochromocytomas, 10% carcinomas and 5% adenomas.The rest were two neural crest derived tumors, one calcifiedcyst, one myelolipoma and one metastatic renal carcinoma.CONCLUSION: The diagnostic and therapeutic aspectsof adrenal disease are reviewed.